Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells | Zendy

Maxwell Tracy | Zendy; Mitchell Lee | Zendy; Brady L Hearn | Zendy; Ian T. Dowsett | Zendy; Luke C. Thurber | Zendy; Jason Loo | Zendy; Anisha M. Loeb | Zendy; Kent Preston | Zendy; Miles I. Tuncel | Zendy; Niloufar Ghodsian | Zendy; Anna Bode | Zendy; Thao T. Tang | Zendy; Andy R. Chia | Zendy; Alan J. Herr | Zendy

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Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

Author(s) -

Maxwell Tracy,

Mitchell Lee,

Brady L Hearn,

Ian T. Dowsett,

Luke C. Thurber,

Jason Loo,

Anisha M. Loeb,

Kent Preston,

Miles I. Tuncel,

Niloufar Ghodsian,

Anna Bode,

Thao T. Tang,

Andy R. Chia,

Alan J. Herr

Publication year - 2020

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.120.303333

Subject(s) - biology , saccharomyces cerevisiae , genetics , dna replication , mutation , mutation rate , dna , replication (statistics) , saccharomyces , extinction (optical mineralogy) , gene , virology , paleontology

“Mutator” tumor cells that cannot correct DNA replication errors exhibit an extremely high mutation rate that accelerates their evolution. But this gamble puts them at risk for extinction....

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