Open AccessMetagenomic Next-Generation Sequencing in the Diagnosis of Deep Sternal Wound Infection After Cardiac Transplantation: A Case Report and Literature Review
Author(s) -
Jiongbiao Yu,
Rongjie Wu,
Bing Xiong,
Zhifeng Huang,
Hanhua Li
Publication year - 2021
Publication title -
the heart surgery forum/the heart surgery forum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.255
H-Index - 38
eISSN - 1522-6662
pISSN - 1098-3511
DOI - 10.1532/hsf.4169
Subject(s) - medicine , wound infection , surgery , debridement (dental) , coinfection , transplantation , surgical wound , wound care , human immunodeficiency virus (hiv) , virology
Purpose: To explore the value of metagenomics next-generation sequencing (mNGS) for deep sternal wound infection (DSWI) diagnosis.Methods: mNGS was used to diagnose DSWI after cardiac transplantation; DSWI was treated with surgical debridement, wound care, and antibiotic therapy guided by mNGS.Results: Coinfection of methicillin-resistant Staphylococcus aureus (MRSA) and cytomegalovirus (CMV) was detected in this patient. The infection was controlled and the wound healed successfully with the specific medicine based on mNGS results for 3 weeks.Conclusion: mNGS is effective to achieve precise, individualized, and rapid treatment for wound infection.