Open AccessPotency of Bioactive Compound of Rice Bran for Colon Cancer Prevention
Author(s) -
Safrida Safrida,
Slamet Budijanto,
Lilis Nuraida,
Bambang Pontjo Priosoeryanto
Publication year - 2020
Publication title -
kemas
Language(s) - English
Resource type - Journals
eISSN - 2355-3596
pISSN - 1858-1196
DOI - 10.15294/kemas.v16i2.21133
Subject(s) - ferulic acid , chemistry , protocatechuic acid , bran , caffeic acid , luteolin , biochemistry , gallic acid , tricin , rutin , apigenin , antioxidant , phytic acid , pharmacology , traditional medicine , biology , medicine , flavonoid , raw material , organic chemistry
Colon cancer is the second leading cause of death in the world. Bioactive compounds in rice bran have a very active role as antiproliferation of colon cancer cells such as ferulic acid, p-coumaric acid, caffeic acid, gallic acid, protocatechuic acid, sinapic acid, tricin, luteolin, apigenin, myrecitin, rutin, isorhamnetin, γ-oryzanol, γ-tocopherol, δ-tocopherol, γ-tocotrienol, β-sitosterol, phytic acid, and hemicellulose. Mechanism of the bioactive compounds in cells varied, including modulation of a cell cycle, activation of immune cells, damage of a lipid layer and mitochondrial membrane, activation of caspase proteins, inhibition of protein cell tumor invasion, metastasis, and angiogenesis, and also acts as an antioxidant. Therefore, the existence of the scientific studies results of this review with the potential availability of adequate rice bran in Indonesia is very potential to be developed.