Open AccessSurface Modification With Gelatin For Polyurethane Vascular Grafts: A Review
Author(s) -
Iman Adipurnama,
Ming Yang,
Tomasz Ciach,
Beata Butruk Raszeja
Publication year - 2020
Publication title -
jurnal bahan alam terbarukan /jurnal bahan alam terbarukan
Language(s) - English
Resource type - Journals
eISSN - 2407-2370
pISSN - 2303-0623
DOI - 10.15294/jbat.v8i2.23170
Subject(s) - polyurethane , gelatin , materials science , synthetic polymer , polymer , surface modification , natural polymers , biocompatible material , coating , grafting , biomedical engineering , adhesion , nanotechnology , chemical engineering , composite material , chemistry , medicine , organic chemistry , engineering
The means for developing synthetic vascular grafts to replace blood vessels is increasing extensively because of the limited supply of autologous vessels. Synthetic polymers as the alternatives still suffer from restenosis and thrombus formation. Natural polymers, on the other hand, are commonly biocompatible and biodegradable, compliment the synthetic ones. Blending, grafting and coating of natural polymers have been proposed to improve surface properties of synthetic polymers. Gelatin is a promising candidate to help improving synthetic vascular grafts surface owing to its ability to promote cell adhesion without promoting platelet aggregation at its surface. In this review, several techniques to incorporate gelatin onto synthetic polymers, mainly polyurethane, for vascular grafts application are summarized, together with the recent updates and potential development in the future.