Open AccessDo the Fibroblasts Contained in Early Passage MSC Population Adversely Affect the Characteristics of Stem Cell Population Obtained from Human Placenta?
Author(s) -
Jun-Woo Ha,
Jina Kim,
ChulWon Ha
Publication year - 2012
Publication title -
international journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 23
eISSN - 2005-5447
pISSN - 2005-3606
DOI - 10.15283/ijsc.2012.5.2.89
Subject(s) - population , mesenchymal stem cell , microbiology and biotechnology , stem cell , biology , andrology , cellular differentiation , cell , fibroblast , adipogenesis , immunology , cell culture , medicine , genetics , environmental health , gene
Mesenchymal stem cells (MSCs) have been obtained from various human tissues by harvesting plastic adherent fibroblast-like cell population. For potential use in regeneration medicine, early passage MSC population is preferred to avoid cell senescence. The early passage adherent cell population contains MSCs as well as fibroblasts, however, the significance of the contained fibroblasts has not been well investigated. Thus, we investigated the stem cell characteristics of the early passage MSC population with and without fibroblasts depletion.