Open AccessSIRT1 Inhibits p53 but not NF-ՊB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies
Author(s) -
Sang Jae Lhee,
Eunkyung Song,
Yuri Kim,
MyungKwan Han
Publication year - 2012
Publication title -
international journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 23
eISSN - 2005-5447
pISSN - 2005-3606
DOI - 10.15283/ijsc.2012.5.2.125
Subject(s) - embryoid body , transactivation , embryonic stem cell , biology , microarray analysis techniques , transcription factor , microbiology and biotechnology , gene expression , signal transduction , knockout mouse , gene , induced pluripotent stem cell , genetics
SIRT1, a histone diacetylase, modify transactivation function of various transcription factor including p53 and NF-κB. p53 and NF-κB is involved in in vitro differentiation of mouse embryonic stem cells (mESC) into mouse embryoid body (mEB). These suggest that SIRT1 might affect in vitro differentiation of mESC into mEB by regulation of p53 and NF-κB.