Open AccessIn vitro anti-inflammatory and cytotoxicity studies of two mangrove associated lichens, Dirinaria consimilis and Ramalina leiodea extracts
Author(s) -
Vinay Bharadwaj Tatipamula,
Girija Sastry Vedula
Publication year - 2018
Publication title -
hygeia : journal for drugs and medicine/hygeia : journal of drugs and medicine
Language(s) - English
Resource type - Journals
eISSN - 2229-3590
pISSN - 0975-6221
DOI - 10.15254/h.j.d.med.10.2018.174
Subject(s) - cytotoxicity , hela , lichen , chemistry , ic50 , acetone , anti inflammatory , in vitro , inflammation , pharmacology , biochemistry , traditional medicine , biology , botany , medicine , immunology
Plan: To evaluate the anti-inflammatory and cytotoxicity activity of different extracts from two different manglicolous lichens (Dirinaria consimilis and Ramalina leiodea).Preface: Inflammation is the origin of several deadly diseases like cancer, atherosclerosis, Alzheimer’s and rheumatoid arthritis. From decades, lichen extracts and its metabolites are well known in treating inflammation and cancer.Outcome: The outcome of protein denaturation method confirmed that the ethyl acetate and acetone extract of R. leiodea depicted better inhibitory profile against protein denaturation with IC50 values of 268 and 330 µg/mL Furthermore, the results of SRB assay showed that ethyl acetate and acetone extracts of both the lichens acts potently against MCF-7, DLD-1, HeLa and A549. Simultaneously, all the tested extracts depicted the low degree of specificity towards NHME, they are less toxic. Hence, further screening of these extracts may lead to the exploration of safe and potent anti-inflammatory and anticancer agents.