Open AccessUnlocking the chromatin code by deciphering protein– DNA interactions
Author(s) -
Bensaddek Dalila,
Lamond Angus I
Publication year - 2016
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.15252/msb.20167332
Subject(s) - proteomics , biology , chromatin , computational biology , research centre , protein expression , gene expression , gene , library science , genetics , computer science
Characterizing the composition of protein complexes bound to different genomic loci is essential for advancing our mechanistic understanding of transcriptional regulation. In their recent study, Krijgsveld and colleagues (Rafiee et al , [Rafiee MR, 2016]) report Ch IP ‐ SICAP , a powerful tool for deciphering the chromatin proteome by combining chromatin immunoprecipitation, selective isolation of chromatin‐associated proteins and mass spectrometry.