Open AccessThe interdependence of transcript and protein abundance: new data–new complexities
Author(s) -
Liu Yansheng,
Aebersold Ruedi
Publication year - 2016
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.15252/msb.20156720
Subject(s) - biology , endoplasmic reticulum , transcriptome , gene , messenger rna , gene expression , proteomics , proteome , abundance (ecology) , unfolded protein response , regulation of gene expression , computational biology , genetics , microbiology and biotechnology , ecology
The relative contribution of transcriptional and translational regulation in gene expression control has been intensely debated and remains a challenging question. Recent reports have suggested that protein abundance in mammalian cells is primarily controlled at the transcript‐level. In their recent work, Cheng et al ([Cheng Z, 2016]) determined the proteomic and transcriptomic changes in cells responding to endoplasmic reticulum ( ER ) stress. Their analyses indicate that the ER stress response is significantly controlled at both the transcript and protein levels.