Open AccessKinase‐two‐hybrid: towards the conditional interactome
Author(s) -
Ochoa David,
Beltrao Pedro
Publication year - 2015
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.15252/msb.20156107
Subject(s) - interactome , biology , computational biology , phosphorylation , yeast , systems biology , biological network , kinase , protein–protein interaction , interaction network , tyrosine kinase , microbiology and biotechnology , bioinformatics , signal transduction , genetics , gene
The dynamics of the protein–protein interaction network and how it responds to biological perturbations remain difficult to assay by most traditional techniques. A novel kinase‐dependent yeast two‐hybrid framework by Stelzl and colleagues (Grossmann et al , 2015) provides a new prism to study how tyrosine phosphorylation regulates the changes in the interactome under varying conditions.