Open AccessDendritic cell cross‐dressing and tumor immunity
Author(s) -
MartinezUsatorre Amaia,
De Palma Michele
Publication year - 2022
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.202216523
Subject(s) - cross presentation , major histocompatibility complex , cytotoxic t cell , antigen presentation , antigen , microbiology and biotechnology , mhc class i , biology , cd8 , immune system , dendritic cell , immunity , immunology , chemistry , t cell , in vitro , biochemistry
In addition to direct and cross‐presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism called “cross‐dressing.” DC cross‐dressing involves the acquisition of preformed peptide‐major histocompatibility class I/II (p‐MHC) complexes from cancer cells. This process has been documented both in cell culture and in tumor models; may occur via the uptake of tumor‐derived extracellular vesicles or the horizontal transfer of plasma membrane fragments from cancer cells to DCs; and can be enhanced through DC engineering for therapeutic applications. In some experimental contexts, DC cross‐dressing may be essential for productive anti‐tumor immunity, possibly owing to the fact that tumor‐derived p‐MHC complexes encompass the full repertoire of immunologically relevant TAs against which primed cytotoxic T cells can exert their tumoricidal activity.