Open AccessTherapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation
Author(s) -
Pal Ravi,
Battu Madhu Babu,
Mukhopadhyay Sangita
Publication year - 2022
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.202114891
Subject(s) - inflammation , mycobacterium tuberculosis , population , mast cell , tuberculosis , immunology , chemistry , microbiology and biotechnology , pharmacology , biology , medicine , pathology , environmental health
There is an increasing need to develop biological anti‐inflammatory agents that are more targeted, effective, and with lesser side effects as compared to conventional chemical drugs. In the present study, we found that Mycobacterium tuberculosis protein PPE2 and a synthetic derivative peptide can suppress the mast cell population and inhibit several vasoactive and fibrogenic mediators and pro‐inflammatory cytokines induced by mast cells in formalin‐induced tissue injury. PPE2 was found to inhibit transcription from the promoter of stem cell factor, important for mast cell maintenance and migration. Thus, PPE2/peptide can be used as a potent nonsteroidal therapeutic agent for the treatment of inflammation and tissue injury.