Open AccessDiscovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth
Author(s) -
Ohn Jungyoon,
Been Kyung Wook,
Kim Jin Yong,
Kim Eun Ju,
Park Taeyong,
Yoon HyeJin,
Ji Jeong Seok,
OkadaIwabu Miki,
Iwabu Masato,
Yamauchi Toshimasa,
Kim Yeon Kyung,
Seok Chaok,
Kwon Ohsang,
Kim Kyu Han,
Lee Hyung Ho,
Chung Jin Ho
Publication year - 2021
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.202013790
Subject(s) - hair follicle , pentapeptide repeat , adiponectin , adiponectin receptor 1 , hair cycle , hair loss , in vivo , microbiology and biotechnology , transdermal , receptor , ex vivo , pharmacology , endocrinology , chemistry , medicine , biology , peptide , biochemistry , insulin resistance , genetics , insulin
Alopecia induced by aging or side effects of medications affects millions of people worldwide and impairs the quality of life; however, there is a limit to the current medications. Here, we identify a small transdermally deliverable 5‐mer peptide (GLYYF; P5) that activates adiponectin receptor 1 (AdipoR1) and promotes hair growth. P5 sufficiently reproduces the biological effect of adiponectin protein via AMPK signaling pathway, increasing the expression of hair growth factors in the dermal papilla cells of human hair follicle. P5 accelerates hair growth ex vivo and induces anagen hair cycle in mice in vivo . Furthermore, we elucidate a key spot for the binding between AdipoR1 and adiponectin protein using docking simulation and mutagenesis studies. This study suggests that P5 could be used as a topical peptide drug for alleviating pathological conditions, which can be improved by adiponectin protein, such as alopecia.