Open AccessTargeting cardiac hypertrophy through a nuclear co‐repressor
Author(s) -
Grund Andrea,
Heineke Joerg
Publication year - 2019
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201911297
Subject(s) - cardiac hypertrophy , repressor , nuclear protein , chemistry , muscle hypertrophy , medicine , microbiology and biotechnology , computational biology , cancer research , transcription factor , biology , biochemistry , gene
Heart failure entails the inability of the heart to pump blood to vital organs. One of the main risk factors for heart failure is the development of pathological hypertrophy. In this issue of EMBO Molecular Medicine , Li and coworkers show that NCoR1, a co‐repressor of transcription factors, inhibits the transcriptional activity of MEF 2 by stabilizing its complex with class II HDAC s. By this mechanism, NC oR1 was identified as potent inhibitor of pathological cardiac hypertrophy and dysfunction.