Targeting cardiac hypertrophy through a nuclear co‐repressor | Zendy

Grund Andrea | Zendy; Heineke Joerg | Zendy

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Targeting cardiac hypertrophy through a nuclear co‐repressor

Author(s) -

Grund Andrea,

Heineke Joerg

Publication year - 2019

Publication title -

embo molecular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.923

H-Index - 107

eISSN - 1757-4684

pISSN - 1757-4676

DOI - 10.15252/emmm.201911297

Subject(s) - german , library science , medicine , political science , management , economics , archaeology , history , computer science

Heart failure entails the inability of the heart to pump blood to vital organs. One of the main risk factors for heart failure is the development of pathological hypertrophy. In this issue of EMBO Molecular Medicine , Li and coworkers show that NCoR1, a co‐repressor of transcription factors, inhibits the transcriptional activity of MEF 2 by stabilizing its complex with class II HDAC s. By this mechanism, NC oR1 was identified as potent inhibitor of pathological cardiac hypertrophy and dysfunction.

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