Open AccessEfficacy of simultaneous VEGF ‐A/ ANG ‐2 neutralization in suppressing spontaneous choroidal neovascularization
Author(s) -
Foxton Richard H,
Uhles Sabine,
Grüner Sabine,
Revelant Franco,
Ullmer Christoph
Publication year - 2019
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201810204
Subject(s) - medicine , library science , computer science
This study independently confirms in vivo in the JR 5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF ‐A and ANG ‐2 neutralization using a bispecific anti‐ VEGF ‐A/ ANG ‐2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.