Efficacy of simultaneous  VEGF ‐A/ ANG ‐2 neutralization in suppressing spontaneous choroidal neovascularization | Zendy

Foxton Richard H | Zendy; Uhles Sabine | Zendy; Grüner Sabine | Zendy; Revelant Franco | Zendy; Ullmer Christoph | Zendy

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Efficacy of simultaneous VEGF ‐A/ ANG ‐2 neutralization in suppressing spontaneous choroidal neovascularization

Author(s) -

Foxton Richard H,

Uhles Sabine,

Grüner Sabine,

Revelant Franco,

Ullmer Christoph

Publication year - 2019

Publication title -

embo molecular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.923

H-Index - 107

eISSN - 1757-4684

pISSN - 1757-4676

DOI - 10.15252/emmm.201810204

Subject(s) - choroidal neovascularization , vegf receptors , neutralization , neovascularization , chemistry , microbiology and biotechnology , cancer research , angiogenesis , biology , virology , biochemistry , retinal , virus

This study independently confirms in vivo in the JR 5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF ‐A and ANG ‐2 neutralization using a bispecific anti‐ VEGF ‐A/ ANG ‐2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.

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