Open AccessColorectal cancer‐initiating cells caught in the act
Author(s) -
Dieter Sebastian M,
Glimm Hanno,
Ball Claudia R
Publication year - 2017
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201707858
Subject(s) - cancer , metastasis , colorectal cancer , cancer research , cancer stem cell , cancer cell , medicine , biology
Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells ( TIC ) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew and differentiate, thereby continuously fueling tumor growth and metastasis formation. This process was previously thought to be unidirectional. Self‐renewing TIC therefore represent highly attractive targets for therapeutic intervention.