Open AccessThe fiendish behavior of TNF can be counteracted by micro RNA
Author(s) -
Cavaillon JeanMarc
Publication year - 2015
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201505380
Subject(s) - tumor necrosis factor alpha , inflammation , immunology , psoriasis , cytokine , microrna , rheumatoid arthritis , medicine , proinflammatory cytokine , biology , genetics , gene
Tumor necrosis factor ( TNF ) is a fascinating anti‐tumoral cytokine, which plays a key role in orchestrating the fight of innate immunity against infection. Concomitantly, TNF is a major player of the inflammatory response, as illustrated by successful therapeutic strategies targeting TNF in patho logies such as Crohn's diseases, rheumatoid arthritis or psoriasis. In mice, TNF is able to induce tissue injuries and lethal shock. In this issue of EMBO Molecular Medicine, Puimège et al ([Puimège L, 2015]) elegantly demonstrated that the lethal shock induced by TNF reflects high levels of its receptor TNFRI as seen in sensitive ( Mus musculus ), vs. resistant ( Mus spretus ) mice, where TNFR 1 expression is low. They reported that this expression is under the control of a micro RNA (miR‐511), which itself is induced by glucocorticoids.