Open AccessFAT FLUX : enzymes, regulators, and pathophysiology of intracellular lipolysis
Author(s) -
Zechner Rudolf
Publication year - 2015
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201404846
Subject(s) - lipolysis , bioinformatics , medicine , physiology , biology , adipose tissue , endocrinology
The great 19 th century French physiologist Claude Bernard reasoned “Man can learn nothing except by going from the known to the unknown”. This premise is particularly applicable to the progression of discoveries made in the field of fat metabolism since Bernard's time. Beginning with his groundbreaking discovery of fat digestion (later termed “lipolysis”) in 1848, research addressing the basic processes of cellular storage and mobilization of fat has steadily advanced. Even after 150 years of research dedicated to lipolysis, exciting new principles have continued to emerge in the last 10 years. This Perspective summarizes these recent landmark discoveries in the field and emphasizes their relevance for the pathogenesis of extremely prevalent diseases such as obesity, heart disease, and cancer.