Open AccessNew TB treatments hiding in plain sight
Author(s) -
Olive Andrew J,
Sassetti Christopher M
Publication year - 2015
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201404815
Subject(s) - mycobacterium tuberculosis , tuberculosis , pathogen , medicine , microbiology and biotechnology , autophagy , virology , biology , immunology , pathology , genetics , apoptosis
As tuberculosis (TB) toll is revised upward according to the WHO's last estimates, the lack of vaccine strategy and the lengthy antibiotic treatments that unfortunately promote the emergence of drug resistance are a major set back in the fight against this pathogen. In this issue of EMBO Molecular Medicine , Schiebler et al ([Schiebler M, 2015]) propose a novel and compelling new approach to target Mycobacterium tuberculosis (Mtb) by pharmacologically stimulating intracellular mycobacteria clearance through autophagy.