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open-access-imgOpen AccessSuppressing nonsense—a surprising function for 5‐azacytidine
Author(s)
Shao Ada,
Wilkinson Miles F
Publication year2014
Publication title
embo molecular medicine
Resource typeJournals
PublisherWiley
In this issue of EMBO Molecular Medicine , Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental because it eliminates “useful” garbage. The chemical inhibitor identified by Bhuvanagiri et al perturbs Nonsense‐Mediated RNA Decay ( NMD ), a RNA surveillance pathway that targets mRNA s harboring premature termination codons ( PTC s) for degradation (Kervestin & Jacobson, [Kervestin S, 2012]).
Subject(s)biochemistry , biology , chemistry , computational biology , computer science , function (biology) , gene , microbiology and biotechnology , nonsense
Language(s)English
SCImago Journal Rank4.923
H-Index107
eISSN1757-4684
pISSN1757-4676
DOI10.15252/emmm.201404569

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