Open AccessSuppressing nonsense—a surprising function for 5‐azacytidine
Author(s) -
Shao Ada,
Wilkinson Miles F
Publication year - 2014
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201404569
Subject(s) - nonsense mediated decay , nonsense , rna , microbiology and biotechnology , messenger rna , function (biology) , chemistry , biology , cancer research , computational biology , biochemistry , gene , rna splicing
In this issue of EMBO Molecular Medicine , Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental because it eliminates “useful” garbage. The chemical inhibitor identified by Bhuvanagiri et al perturbs Nonsense‐Mediated RNA Decay ( NMD ), a RNA surveillance pathway that targets mRNA s harboring premature termination codons ( PTC s) for degradation (Kervestin & Jacobson, [Kervestin S, 2012]).