Open AccessEvolving targets for lipid‐modifying therapy
Author(s) -
Do Rose Q,
Nicholls Stephen J,
Schwartz Gregory G
Publication year - 2014
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201404000
Subject(s) - pathogenesis , lipoprotein , function (biology) , triglyceride , receptor , computational biology , bioinformatics , medicine , biology , microbiology and biotechnology , biochemistry , cholesterol , immunology
The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low‐density lipoprotein and lipoprotein (a), triglyceride‐rich lipoproteins, and high‐density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed.