Open AccessDevelopment of micro RNA therapeutics is coming of age
Author(s) -
Rooij Eva,
Kauppinen Sakari
Publication year - 2014
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.15252/emmm.201100899
Subject(s) - rna , cancer , microrna , medicine , computational biology , biology , cancer research , virology , gene , genetics
Micro RNA s (mi RNA s) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, mi RNA s have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of mi RNA s and provide an update on the development of mi RNA ‐based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus ( HCV ) infection.