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Histone clipping: the punctuation in the histone code
Author(s) -
Dhaenens Maarten
Publication year - 2021
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202153440
Subject(s) - histone , biology , computational biology , genetics , gene
Histone clipping was first discovered in the 1960s and still is a lingering mystery. Considering the essential roles of histones in regulating eukaryotic transcription through the histone code, clipping is a post‐translational modification that appeals to the imagination. In this issue of EMBO Reports , Marruecos and colleagues investigate histone H4 clipping during intestinal development (Marruecos et al , 2021), and are providing crucial clues to finally elucidate the intricacies of this elusive modification.