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Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice
Author(s) -
Chen Qi,
Lai Si Min,
Xu Shaohai,
Tan Yingrou,
Leong Keith,
Liu Dehua,
Tan Jia Chi,
Naik Roshan Ratnakar,
Barron Anna M,
Adav Sunil S,
Chen Jinmiao,
Chong Shu Zhen,
Ng Lai Guan,
Ruedl Christiane
Publication year - 2021
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202152835
Subject(s) - white adipose tissue , adipose tissue , fibrosis , adipose tissue macrophages , extracellular matrix , microbiology and biotechnology , adipocyte , biology , endocrinology , medicine
Tissue‐resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity‐driven WAT remodeling remains controversial. Here, using a transgenic CD169‐DTR mouse strain, we provide new insights into the interplay between CD169 + adipose tissue macrophages (ATMs) and their surrounding WAT microenvironment. Using targeted in vivo ATM ablation followed by transcriptional and metabolic WAT profiling, we found that ATMs protect WAT from the excessive pathological remodeling that occurs during obesity. As obesity progresses, ATMs control not only vascular integrity, adipocyte function, and lipid and metabolic derangements but also extracellular matrix accumulation and resultant fibrosis in the WAT. The protective role of ATMs during obesity‐driven WAT dysfunction supports the notion that ATMs represent friends, rather than foes, as has previously assumed.