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Maintaining proteostasis under mechanical stress
Author(s) -
Höhfeld Jörg,
Benzing Thomas,
Bloch Wilhelm,
Fürst Dieter O,
Gehlert Sebastian,
Hesse Michael,
Hoffmann Bernd,
Hoppe Thorsten,
Huesgen Pitter F,
Köhn Maja,
Kolanus Waldemar,
Merkel Rudolf,
Niessen Carien M,
Pokrzywa Wojciech,
Rinschen Markus M,
Wachten Dagmar,
Warscheid Bettina
Publication year - 2021
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202152507
Subject(s) - german , library science , classics , proteostasis , history , computer science , biology , genetics , archaeology
Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force‐unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.