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Connecting autoimmune disease to Bardet–Biedl syndrome and primary cilia
Author(s) -
Kanie Tomoharu,
Jackson Peter K
Publication year - 2021
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202052180
Subject(s) - bardet–biedl syndrome , cilium , ciliopathy , disease , autoimmune disease , biology , genetics , medicine , immunology , phenotype , gene
Bardet–Biedl syndrome (BBS) is a genetic disorder caused by the dysfunction of the primary cilium. To date, immunological defects in the disease have not been systematically assessed. In this issue, Tsyklauri and colleagues find, through detailed analysis of BBS mutant animals, that B‐cell development is altered in mutant mice (Tsyklauri et al , 2021). The authors further report that BBS patients are more susceptible to autoimmune disorders. This study sheds new light on the potential role of primary cilia in controlling immune function in disease.