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Supercomplex formation boosts respiration
Author(s) -
Brave Fabian,
Becker Thomas
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202051830
Subject(s) - cytochrome c oxidase , electron transport chain , coenzyme q – cytochrome c reductase , biology , alternative oxidase , respiratory chain , respiration , cytochrome b , electron transport complex iv , cytochrome c , biochemistry , mitochondrion , cellular respiration , yeast , microbiology and biotechnology , mitochondrial dna , gene , anatomy
Mitochondrial respiratory chain complexes associate in supercomplexes, but the physiological role of these assemblies remains controversial. Recent studies in EMBO Reports reveal that supercomplexes promote metabolic fitness. Berndtsson et al (2020) demonstrate that supercomplex formation enhances electron transport by reducing the distance for diffusion of cytochrome c between cytochrome bc 1 complex and cytochrome c oxidase and thereby increases competitive fitness in yeast. Similarly, Garcia‐Poyatos et al (2020) report that zebrafish lacking the supercomplex assembly factor SCAF1 display a reduced growth and decreased female fertility.