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Irgm2 and Gate‐16 put a break on caspase‐11 activation
Author(s) -
Linder Andreas,
Hornung Veit
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202051787
Subject(s) - pyroptosis , inflammasome , microbiology and biotechnology , innate immune system , caspase 1 , caspase , aim2 , intracellular , tlr4 , biology , extracellular , cytoplasm , caspase 8 , programmed cell death , chemistry , receptor , signal transduction , apoptosis , biochemistry
Non‐canonical inflammasome activation is crucial to mount an immune response against bacteria. Two studies in this issue show that the IFN‐inducible protein Irgm2 and the ATG8 family member Gate‐16 cooperatively limit the non‐canonical inflammasome.