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Chromatin accessibility dynamics during cell fate reprogramming
Author(s) -
Li Dongwei,
Shu Xiaodong,
Zhu Ping,
Pei Duanqing
Publication year - 2021
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202051644
Subject(s) - chromatin , reprogramming , cell fate determination , biology , microbiology and biotechnology , somatic cell , bivalent chromatin , fate mapping , computational biology , transcription factor , cell , chromatin remodeling , genetics , stem cell , dna , progenitor cell , gene
Genome architecture and chromatin dynamics govern the fate and identify of a cell. Recent advances in mapping chromatin landscapes offer valuable tools for the acquisition of accurate information regarding chromatin dynamics. Here we discuss recent findings linking chromatin dynamics to cell fate control. Specifically, chromatin undergoes a binary off/on switch during iPSC reprogramming, closing and opening loci occupied by somatic and pluripotency transcription factors, respectively. This logic of a binary off/on switch may also be operational in cell fate control during normal development and implies that further approaches could potentially be developed to direct cell fate changes both in vitro and in vivo .