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LRP 6 lets Merlin go in times of nutrient scarcity
Author(s) -
Wong Kenneth Kin Lam,
Verheyen Esther M
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202051358
Subject(s) - library science , scarcity , plant biology , biology , history , genealogy , computer science , economics , microeconomics , botany
Cells take advantage of cross‐talk in signaling pathways to integrate diverse signals and produce coordinated responses. In this issue of EMBO Reports, Jeong et al discover that the Wnt co‐receptor, low‐density lipoprotein ( LDL ) receptor‐related protein LRP 6, negatively regulates Hippo signaling by serving as a binding sink to sequester and inhibit Merlin, an activator of Hippo signaling (Jeong et al , 2020). This regulation is nutrient‐responsive, likely using LRP 6 O‐ Glc NA cylation as a molecular switch.