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HP1c regulates development and gut homeostasis by suppressing Notch signaling through Su(H)
Author(s) -
Sun Jin,
Wang Xia,
Xu RongGang,
Mao Decai,
Shen Da,
Wang Xin,
Qiu Yuhao,
Han Yuting,
Lu Xinyi,
Li Yutong,
Che Qinyun,
Zheng Li,
Peng Ping,
Kang Xuan,
Zhu Ruibao,
Jia Yu,
Wang Yinyin,
Liu LuPing,
Chang Zhijie,
Ji JunYuan,
Wang Zhao,
Liu Qingfei,
Li Shao,
Sun FangLin,
Ni JianQuan
Publication year - 2021
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202051298
Subject(s) - notch signaling pathway , biology , transcription factor , epigenetics , microbiology and biotechnology , hes3 signaling axis , hairless , cyclin dependent kinase 8 , notch proteins , regulator , phenotype , signal transduction , genetics , gene
Abstract Notch signaling and epigenetic factors are known to play critical roles in regulating tissue homeostasis in most multicellular organisms, but how Notch signaling coordinates with epigenetic modulators to control differentiation remains poorly understood. Here, we identify heterochromatin protein 1c (HP1c) as an essential epigenetic regulator of gut homeostasis in Drosophila . Specifically, we observe that HP1c loss‐of‐function phenotypes resemble those observed after Notch signaling perturbation and that HP1c interacts genetically with components of the Notch pathway. HP1c represses the transcription of Notch target genes by directly interacting with Suppressor of Hairless (Su(H)), the key transcription factor of Notch signaling. Moreover, phenotypes caused by depletion of HP1c in Drosophila can be rescued by expressing human HP1γ, suggesting that HP1γ functions similar to HP1c in Drosophila . Taken together, our findings reveal an essential role of HP1c in normal development and gut homeostasis by suppressing Notch signaling.