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Lipoic acid and autophagy: new insights into stem cell aging
Author(s) -
Zhang Peng,
Edgar Bruce A
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202051175
Subject(s) - salt lake , library science , gerontology , biology , medicine , computer science , paleontology , structural basin
The gastrointestinal tract undergoes homeostatic self‐renewal to replace aged and damaged epithelial cells. This process, sustained by intestinal stem cells ( ISC s), can operate accurately for many years but gradually declines with age. Although stem cell aging has been intensively explored, the mechanisms remain poorly understood. In this issue of EMBO Reports , Du et al report that alpha‐lipoic acid ( ALA ) sustains an active endocytosis–autophagy network that effectively reverses age‐dependent ISC hyperplasia in Drosophila (Du et al , 2020). This work suggests a new strategy for treating aging‐associated gastrointestinal diseases.