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Hair follicle stem cell progeny heal blisters while pausing skin development
Author(s) -
Fujimura Yu,
Watanabe Mika,
Ohno Kota,
Kobayashi Yasuaki,
Takashima Shota,
Nakamura Hideki,
Kosumi Hideyuki,
Wang Yunan,
Mai Yosuke,
Lauria Andrea,
Proserpio Valentina,
Ujiie Hideyuki,
Iwata Hiroaki,
Nishie Wataru,
Nagayama Masaharu,
Oliviero Salvatore,
Donati Giacomo,
Shimizu Hiroshi,
Natsuga Ken
Publication year - 2021
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202050882
Subject(s) - hair follicle , blisters , regeneration (biology) , stem cell , epidermis (zoology) , morphogenesis , microbiology and biotechnology , biology , wound healing , developmental biology , skin repair , cell growth , pathology , immunology , anatomy , gene , medicine , genetics
Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it is not known whether this paradigm applies to growing tissue. Here, by employing blisters, we show that epidermal wounds heal at the expense of skin development. The regenerated epidermis suppresses the expression of tissue morphogenesis genes accompanied by delayed hair follicle (HF) growth. Lineage tracing experiments, cell proliferation dynamics, and mathematical modeling reveal that the progeny of HF junctional zone stem cells, which undergo a morphological transformation, repair the blisters while not promoting HF development. In contrast, the contribution of interfollicular stem cell progeny to blister healing is small. These findings demonstrate that HF development can be sacrificed for the sake of epidermal wound regeneration. Our study elucidates the key cellular mechanism of wound healing in skin blistering diseases.