Hijacking the NLRP 3 inflammasome: a mechanism underlying viral respiratory disease?

In contrast to highly specific sensor molecules of the innate immune system, the NLRP 3 receptor detects a broad variety of danger signals including pathogens. Sensing triggers intracellular NLRP 3 inflammasome complex assembly to induce an inflammatory response with the primary aim to eliminate pathogens. However, several of them have developed distinct strategies to hijack NLRP 3‐dependent immunity. In this issue of EMBO Reports , Zhang and colleagues demonstrate that reovirus infection of airway epithelial cells promotes EphA2‐dependent phosphorylation of NLRP 3 that impedes the recruitment of other inflammasome components necessary for its activation [1]. This potentially uncovers a mechanism that may lead to reduced viral clearance in the lung, eventually contributing to life‐threatening respiratory disease.