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Towards restoring proper chromosome segregation and preventing ageing
Author(s) -
Tovini Laura,
McClelland Sarah E
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202050322
Subject(s) - ageing , rejuvenation , biology , mechanism (biology) , chromosome instability , genome instability , chromosome , evolutionary biology , genetics , dna damage , dna , gene , philosophy , epistemology
The natural progressive dysfunction of most living organisms—ageing—has captured the attention of several studies, with the intention to develop rejuvenation strategies. Evidence is emerging of a positive correlation between natural ageing and chromosomal instability ( CIN ). In this issue of EMBO Reports , Barroso‐Vilares et al [1] now show a link between ageing and the erroneous assembly of the apparatus required for a proper cellular division. They compare this mechanism in young and naturally aged human cells and describe a strategy to delay age‐related CIN .