Towards restoring proper chromosome segregation and preventing ageing | Zendy

Tovini Laura | Zendy; McClelland Sarah E | Zendy

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Towards restoring proper chromosome segregation and preventing ageing

Author(s) -

Tovini Laura,

McClelland Sarah E

Publication year - 2020

Publication title -

embo reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.584

H-Index - 184

eISSN - 1469-3178

pISSN - 1469-221X

DOI - 10.15252/embr.202050322

Subject(s) - ageing , rejuvenation , biology , mechanism (biology) , genome instability , chromosome instability , cellular aging , chromosome , evolutionary biology , genetics , telomere , dna damage , dna , gene , philosophy , epistemology

The natural progressive dysfunction of most living organisms—ageing—has captured the attention of several studies, with the intention to develop rejuvenation strategies. Evidence is emerging of a positive correlation between natural ageing and chromosomal instability ( CIN ). In this issue of EMBO Reports , Barroso‐Vilares et al [1] now show a link between ageing and the erroneous assembly of the apparatus required for a proper cellular division. They compare this mechanism in young and naturally aged human cells and describe a strategy to delay age‐related CIN .

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