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Exosomes take (germinal) center stage
Author(s) -
PérezBoza Jennifer,
Pegtel Dirk M
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202050190
Subject(s) - microvesicles , germinal center , biology , stage (stratigraphy) , virology , microrna , immunology , genetics , antibody , gene , b cell , paleontology
Efficient antibody production is a crucial step during immune responses leading to pathogen clearance and neutralization. Immune synapses, contact points between T and B lymphocytes in the presence of an antigen, are necessary to initiate the proliferation and differentiation of B cells in the germinal center. In this issue of EMBO Reports , Fernández‐Messina et al [1] present evidence of microRNA transfer from T to B cells via exosomes during synapse formation and highlight the crucial role of these exosomes for germinal center formation and the efficient production of antigen‐specific antibodies.