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Calcium regulation of stem cells
Author(s) -
Snoeck HansWillem
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202050028
Subject(s) - columbia university , library science , medicine , center (category theory) , gerontology , media studies , sociology , chemistry , computer science , crystallography
Pluripotent and post‐natal, tissue‐specific stem cells share functional features such as the capacity to differentiate into multiple lineages and to self‐renew, and are endowed with specific cell maintenance mechanism as well as transcriptional and epigenetic signatures that determine stem cell identity and distinguish them from their progeny. Calcium is a highly versatile and ubiquitous second messenger that regulates a wide variety of cellular functions. Specific roles of calcium in stem cell niches and stem cell maintenance mechanisms are only beginning to be explored, however. In this review, I discuss stem cell‐specific regulation and roles of calcium, focusing on its potential involvement in the intertwined metabolic and epigenetic regulation of stem cells.