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The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT –liver communication
Author(s) -
Sponton Carlos H,
Hosono Takashi,
Taura Junki,
Jedrychowski Mark P,
Yoneshiro Takeshi,
Wang Qiang,
Takahashi Makoto,
Matsui Yumi,
Ikeda Kenji,
Oguri Yasuo,
Tajima Kazuki,
Shinoda Kosaku,
Pradhan Racha,
Chen Yong,
Brown Zachary,
Roberts Lindsay S,
Ward Carl C,
Taoka Hiroki,
Yokoyama Yoko,
Watanabe Mitsuhiro,
Karasawa Hiroshi,
Nomura Daniel K,
Kajimura Shingo
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201949828
Subject(s) - stem cell , library science , gerontology , medicine , biology , microbiology and biotechnology , computer science
Abstract While brown adipose tissue ( BAT ) is well‐recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of the functions involves interorgan communication with metabolic organs, such as the liver, through BAT ‐derived secretory factors, a.k.a., batokine. However, the identity and the roles of such mediators remain insufficiently understood. Here, we employed proteomics and transcriptomics in human thermogenic adipocytes and identified previously unappreciated batokines, including phospholipid transfer protein ( PLTP ). We found that increased circulating levels of PLTP , via systemic or BAT ‐specific overexpression, significantly improve glucose tolerance and insulin sensitivity, increased energy expenditure, and decrease the circulating levels of cholesterol, phospholipids, and sphingolipids. Such changes were accompanied by increased bile acids in the circulation, which in turn enhances glucose uptake and thermogenesis in BAT . Our data suggest that PLTP is a batokine that contributes to the regulation of systemic glucose and lipid homeostasis as a mediator of BAT ‐liver interorgan communication.