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Placensin is a glucogenic hormone secreted by human placenta
Author(s) -
Yu Yiping,
He JiaHuan,
Hu LinLi,
Jiang LinLin,
Fang Lanlan,
Yao GuiDong,
Wang SiJia,
Yang Qingling,
Guo Yanjie,
Liu Lin,
Shang Trisha,
Sato Yorino,
Kawamura Kazuhiro,
Hsueh Aaron JW,
Sun YingPu
Publication year - 2020
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201949530
Subject(s) - placenta , hormone , human placenta , biology , microbiology and biotechnology , endocrinology , pregnancy , genetics , fetus
FBN 1 encodes asprosin, a glucogenic hormone, following furin cleavage of the C‐terminus of profibrillin 1. Based on evolutionary conservation between FBN 1 and FBN 2, together with conserved furin cleavage sites, we identified a peptide hormone placensin encoded by FBN 2 based on its high expression in trophoblasts of human placenta. In primary and immortalized murine hepatocytes, placensin stimulates cAMP production, protein kinase A ( PKA ) activity, and glucose secretion, accompanied by increased expression of gluconeogenesis enzymes. In situ perfusion of liver and in vivo injection with placensin also stimulate glucose secretion. Placensin is secreted by immortalized human trophoblastic HTR ‐8/ SV neo cells, whereas placensin treatment stimulates cAMP ‐ PKA signaling in these cells, accompanied by increases in MMP 9 transcripts and activities, thereby promoting cell invasion. In pregnant women, levels of serum placensin increase in a stage‐dependent manner. During third trimester, serum placensin levels of patients with gestational diabetes mellitus are increased to a bigger extent compared to healthy pregnant women. Thus, placensin represents a placenta‐derived hormone, capable of stimulating glucose secretion and trophoblast invasion.