Premium
A nuclear licence to silence transposons
Author(s) -
Gould Poppy A,
Rowe Helen M
Publication year - 2019
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201949262
Subject(s) - silence , histone , biology , genetics , philosophy , aesthetics , gene
Transposon silencing requires the histone methyltransferase SETDB 1. In this issue of EMBO Reports , Tsusaka et al [1] and Osumi et al [2] illustrate how the cofactor ATF7IP and its fly homolog Windei (Wde) regulate the methyltransferase function of SETDB1 through its nuclear licensing. The new insight gained from these two articles will shift how we think about epigenetic regulation and its multiple layers of control.