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IRF 1 and IRF 2 regulate the non‐canonical inflammasome
Author(s) -
Thygesen Sara J,
Stacey Katryn J
Publication year - 2019
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201948891
Subject(s) - inflammasome , microbiology and biotechnology , chemistry , biology , receptor , genetics
The non‐canonical inflammasome mediates pyroptotic cell death in response to bacterial lipopolysaccharide ( LPS ) found in the cytosol. Understanding the mechanism and regulation of this system is of great interest, given its central role in mouse models of bacterial septic shock. In this issue of EMBO Reports , Benaoudia and colleagues sought to discover extra players in the human non‐canonical inflammasome using a CRISPR library screen; the only strongly positive hit apart from the known components caspase‐4 and gasdermin D was interferon regulatory factor‐2 ( IRF 2) [ 1 ]. IRF 2 was found to be a transcriptional activator of caspase‐4, and in its absence, induction of IRF 1 could substitute to maintain caspase‐4 expression.