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A tale of two clocks: phosphorylation of NICD by CDK s links cell cycle and segmentation clock
Author(s) -
Braunreiter Kara M,
Cole Susan E
Publication year - 2019
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201948247
Subject(s) - microbiology and biotechnology , phosphorylation , cell cycle , cyclin dependent kinase , biology , genetics , cell
The Notch signaling pathway is tightly controlled via post‐transcriptional regulatory mechanisms that promote or terminate pathway activity. In this issue, Carrieri et al [1] show that phosphorylation of the Notch intracellular domain ( NICD ) by cyclin‐dependent kinases ( CDK s) suppresses Notch activity by promoting NICD turnover. These findings link Notch pathway activity to the cell cycle, and the authors propose connections between this regulation and the segmentation clock that times embryonic somitogenesis.