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The fog of genetics: what is known, unknown and unknowable in the genetics of complex traits and diseases
Author(s) -
Magalhães João Pedro,
Wang Jingwei
Publication year - 2019
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201948054
Subject(s) - ageing , genomics , genetics , gerontology , disease , sanger sequencing , human genetics , medicine , biology , pathology , genome , mutation , gene
A major task for genetics is searching for genetic variants associated with disease. But we may well be missing a large number of “unknown unknown” alleles in the “fog of genetics”.