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T time for ADAR : ADAR 1 is required for T cell self‐tolerance
Author(s) -
Chung Hachung,
Rice Charles M
Publication year - 2018
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201847237
Subject(s) - adar , biology , infectious disease (medical specialty) , virology , disease , medicine , rna , genetics , gene , rna editing , pathology
ADAR 1, an RNA ‐editing enzyme, plays a key role in preventing self‐ RNA s from triggering autoinflammatory responses. In this issue of EMBO reports , Nakahama and colleagues uncover a novel role for ADAR 1 in T cells [1][Nakahama T, 2018]. The authors report that in T cells, ADAR 1‐mediated suppression of type I interferon‐stimulated gene ( ISG ) expression is required for thymic T cell self‐tolerance and prevention of colitis. These findings establish a novel function of ADAR 1 in T cells and suggest that autoreactive T cells may contribute to disease symptoms in autoinflammatory disorders.