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Nup62‐mediated nuclear import of p63 in squamous cell carcinoma
Author(s) -
Borlido Joana,
D'Angelo Maximiliano A
Publication year - 2018
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201745497
Subject(s) - regeneration (biology) , nuclear pore , cancer , library science , biology , cytoplasm , microbiology and biotechnology , computer science , genetics
Nuclear pore complexes ( NPC s) are multiprotein channels that bridge the nucleus with the cytoplasm and regulate all nucleo‐cytoplasmic traffic. NPC s are built by the repetition of ~30 different proteins known as nucleoporins (Nups). Accumulating evidence has revealed a diversity in NPC composition that is critical for cell‐specific functionality and fate determination. A new report by Hazawa et al [1][Hazawa M, 2018] now identifies the central transport channel nucleoporin Nup62 as a novel regulator of cell proliferation and differentiation in squamous cell carcinoma ( SCC ), via modulation of p63 nucleo‐cytoplasmic transport. These findings provide further evidence on how alterations in NPC composition might be utilized to determine cell fate.