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Lipids at membrane contact sites: cell signaling and ion transport
Author(s) -
Muallem Shmuel,
Chung Woo Young,
Jha Archana,
Ahuja Malini
Publication year - 2017
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201744331
Subject(s) - craniofacial , dental research , library science , medicine , biology , bioinformatics , dentistry , genetics , computer science
Communication between organelles is essential to coordinate cellular functions and the cell's response to physiological and pathological stimuli. Organellar communication occurs at membrane contact sites ( MCS s), where the endoplasmic reticulum ( ER ) membrane is tethered to cellular organelle membranes by specific tether proteins and where lipid transfer proteins and cell signaling proteins are located. MCS s have many cellular functions and are the sites of lipid and ion transfer between organelles and generation of second messengers. This review discusses several aspects of MCS s in the context of lipid transfer, formation of lipid domains, generation of Ca 2+ and cAMP second messengers, and regulation of ion transporters by lipids.