Lipids at membrane contact sites: cell signaling and ion transport | Zendy

Muallem Shmuel | Zendy; Chung Woo Young | Zendy; Jha Archana | Zendy; Ahuja Malini | Zendy

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Lipids at membrane contact sites: cell signaling and ion transport

Author(s) -

Muallem Shmuel,

Chung Woo Young,

Jha Archana,

Ahuja Malini

Publication year - 2017

Publication title -

embo reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.584

H-Index - 184

eISSN - 1469-3178

pISSN - 1469-221X

DOI - 10.15252/embr.201744331

Subject(s) - craniofacial , dental research , library science , medicine , bioinformatics , biology , dentistry , genetics , computer science

Communication between organelles is essential to coordinate cellular functions and the cell's response to physiological and pathological stimuli. Organellar communication occurs at membrane contact sites ( MCS s), where the endoplasmic reticulum ( ER ) membrane is tethered to cellular organelle membranes by specific tether proteins and where lipid transfer proteins and cell signaling proteins are located. MCS s have many cellular functions and are the sites of lipid and ion transfer between organelles and generation of second messengers. This review discusses several aspects of MCS s in the context of lipid transfer, formation of lipid domains, generation of Ca 2+ and cAMP second messengers, and regulation of ion transporters by lipids.

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