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Lnc RNA ‐ PAGBC acts as a micro RNA sponge and promotes gallbladder tumorigenesis
Author(s) -
Wu XiangSong,
Wang Fang,
Li HuaiFeng,
Hu YunPing,
Jiang Lin,
Zhang Fei,
Li MaoLan,
Wang XuAn,
Jin YunPeng,
Zhang YiJian,
Lu Wei,
Wu WenGuang,
Shu YiJun,
Weng Hao,
Cao Yang,
Bao RunFa,
Liang HaiBin,
Wang Zheng,
Zhang YiChi,
Gong Wei,
Zheng Lei,
Sun ShuHan,
Liu YingBin
Publication year - 2017
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201744147
Subject(s) - china , shanghai china , medicine , traditional chinese medicine , family medicine , general surgery , pathology , history , alternative medicine , geography , archaeology , regional science
Long noncoding RNA s (lnc RNA s) play roles in the development and progression of many cancers; however, the contributions of lnc RNA s to human gallbladder cancer ( GBC ) remain largely unknown. In this study, we identify a group of differentially expressed lnc RNA s in human GBC tissues, including prognosis‐associated gallbladder cancer lnc RNA (lnc RNA ‐ PAGBC ), which we find to be an independent prognostic marker in GBC . Functional analysis indicates that lnc RNA ‐ PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ce RNA ), lnc RNA ‐ PAGBC competitively binds to the tumour suppressive micro RNA s miR‐133b and miR‐511. This competitive role of lnc RNA ‐ PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT / mTOR pathway. Moreover, lnc RNA ‐ PAGBC interacts with polyadenylate binding protein cytoplasmic 1 ( PABPC 1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC .