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CUE domain‐containing protein 2 promotes the Warburg effect and tumorigenesis
Author(s) -
Zhong Xiuying,
Tian Shengya,
Zhang Xiang,
Diao Xinwei,
Dong Fangting,
Yang Jie,
Li Zhaoyong,
Sun Linchong,
Wang Lin,
He Xiaoping,
Wu Gongwei,
Hu Xin,
Wang Lihua,
Song Libing,
Zhang Huafeng,
Pan Xin,
Li Ailing,
Gao Ping
Publication year - 2017
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201643617
Subject(s) - beijing , china , basic research , chinese academy of sciences , library science , political science , computer science , law
Cancer progression depends on cellular metabolic reprogramming as both direct and indirect consequence of oncogenic lesions; however, the underlying mechanisms are still poorly understood. Here, we report that CUEDC 2 ( CUE domain‐containing protein 2) plays a vital role in facilitating aerobic glycolysis, or Warburg effect, in cancer cells. Mechanistically, we show that CUEDC 2 upregulates the two key glycolytic proteins GLUT 3 and LDHA via interacting with the glucocorticoid receptor ( GR ) or 14‐3‐3ζ, respectively. We further demonstrate that enhanced aerobic glycolysis is essential for the role of CUEDC 2 to drive cancer progression. Moreover, using tissue microarray analysis, we show a correlation between the aberrant expression of CUEDC 2, and GLUT 3 and LDHA in clinical HCC samples, further demonstrating a link between CUEDC 2 and the Warburg effect during cancer development. Taken together, our findings reveal a previously unappreciated function of CUEDC 2 in cancer cell metabolism and tumorigenesis, illustrating how close oncogenic lesions are intertwined with metabolic alterations promoting cancer progression.