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Parkinson's disease‐associated receptor GPR 37 is an ER chaperone for LRP 6
Author(s) -
Berger Birgit S,
Acebron Sergio P,
Herbst Jessica,
Koch Stefan,
Niehrs Christof
Publication year - 2017
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201643585
Subject(s) - chaperone (clinical) , receptor , chemistry , microbiology and biotechnology , biology , biochemistry , medicine , pathology
Wnt/β‐catenin signaling plays a key role in embryonic development, stem cell biology, and neurogenesis. However, the mechanisms of Wnt signal transmission, notably how the receptors are regulated, remain incompletely understood. Here we describe that the Parkinson's disease‐associated receptor GPR 37 functions in the maturation of the N‐terminal bulky β‐propellers of the Wnt co‐receptor LRP 6. GPR 37 is required for Wnt/β‐catenin signaling and protects LRP 6 from ER ‐associated degradation via CHIP (carboxyl terminus of Hsc70‐interacting protein) and the ATP ase VCP . GPR 37 is highly expressed in neural progenitor cells ( NPC s) where it is required for Wnt‐dependent neurogenesis. We conclude that GPR 37 is crucial for cellular protein quality control during Wnt signaling.