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Plants get on PAR with poly( ADP ‐ribosyl)ation
Author(s) -
Menke Frank LH
Publication year - 2016
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201643453
Subject(s) - chromatin , adp ribosylation , dna replication , dna repair , dna damage , mitosis , telomere , poly adp ribose polymerase , chemistry , microbiology and biotechnology , dna , biology , polymerase , genetics , biochemistry , enzyme , nad+ kinase
Poly( ADP ‐ribosyl)ation, or PAR ylation, was first described over 50 years ago. Since then, our understanding of the biochemistry and enzymology of this protein modification has significantly progressed. PAR ylation has long been associated with DNA damage and DNA repair as well as genotoxic stress [1][Kraus WL, 2015][2][Lamb RS, 2012]. However, over the last two decades this has expanded to chromatin remodelling, DNA replication, transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism [1][Kraus WL, 2015]. Most eukaryotes, except yeasts, have genes encoding poly( ADP ‐ribose) polymerases ( PARP s) and poly( ADP ‐ribose) glycohydrolases ( PARG s), and our knowledge on PAR ylation is primarily based on studies in metazoans. In plants, however, mechanistic understanding of the role of ADP ‐ribosylation in stress response is still lacking. In this issue of EMBO Reports, Feng et al [3][Feng B, 2016] identify the first set of PAR ylated plant proteins and show that in vivo PAR ylation of one of these proteins, a factor named DAWDLE , is important for its role in plant immunity.